Target General Information
Target ID	T50942
Target Name	Low-affinity nerve growth factor receptor
Synonyms	75kD-neurotrophin receptor; Gp80-LNGFR; Low-affinity nerve growth factor receptor; Lowaffinity neurotrophin receptor p75NTR; NGF-P75 receptor; NGFreceptor; P75ICD; P75NTR; P75neurotrophin receptor (p75(NTR)); NGFR
Target Type	Clinical Trial
Gene Name	NGFR
Biochemical Class	Cytokine receptor
UniProt ID	TNR16_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Parkinson's disease
Example drug	SPI-205			Phase 2	[521523], [1572592]
Tissue	Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.38 Z-score: 0.37 P-value: 5.08E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Alzheimer's disease
Example drug	CEP-427			Terminated	[546139], [1572592]
Tissue	Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.18 Z-score: 0.40 P-value: 3.92E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Interstitial cystitis
Example drug	ReN-1820			Terminated	[547599], [1572592]
Tissue	Bladder tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.55 Z-score: 2.56 P-value: 8.74E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 546139	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006555)
Ref 547599	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017720)
Ref 521523	ClinicalTrials.gov (NCT00041795) Neotrofin for Treatment of Chemotherapy-Induced Peripheral Neuropathy. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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