Target General Information
Target ID	T52373
Target Name	Farnesyl pyrophosphate synthase
Synonyms	(2E,6E)farnesyl diphosphate synthase; Dimethylallyltranstransferase; FPP synthase; FPS; Farnesyl diphosphate synthase; Geranyltranstransferase; FDPS
Target Type	Successful
Gene Name	FDPS
Biochemical Class	Alkyl aryl transferase
UniProt ID	FPPS_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Osteoporosis
Example drug	Alendronate			Approved	[536664], [540141], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.73 Z-score: -2.57 P-value: 7.06E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 540141	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3141).
Ref 536664	Osteonecrosis of the jaw. South Med J. 2008 Feb;101(2):160-5.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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