Target expression details
Target General Information | |||||
---|---|---|---|---|---|
Target ID | T53524 | ||||
Target Name | PDGF receptor alpha | ||||
Synonyms | CD140a antigen; PDGF-R-alpha; Platelet-derived growth factor receptor alpha; PDGFRA | ||||
Target Type | Successful | ||||
Gene Name | PDGFRA | ||||
Biochemical Class | Kinase | ||||
UniProt ID | PGFRA_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Gastric cancer | ||||
Example drug | CP-868596 | Phase 3 | [1], [2], [3] | ||
Tissue | Gastric tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.23 Z-score: -1.55 P-value: 3.46E-01 |
||||
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.16 Z-score: -0.73 P-value: 1.75E-01 |
||||
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
![]() |
|||||
Disease | Glioma | ||||
Example drug | MEDI-575 | Phase 2 | [4], [3] | ||
Tissue | Brainstem tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.37 Z-score: 3.31 P-value: 4.48E-02 |
||||
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
![]() |
|||||
Disease | Glioma | ||||
Example drug | MEDI-575 | Phase 2 | [4], [3] | ||
Tissue | White matter | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 2.15 Z-score: 1.46 P-value: 9.98E-03 |
||||
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
![]() |
|||||
Disease | Ovarian cancer | ||||
Example drug | Olaratumab | Phase 1 | [5], [3] | ||
Tissue | Ovarian tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -1.66 Z-score: -1.59 P-value: 1.31E-03 |
||||
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.74 Z-score: -1.97 P-value: 1.14E-05 |
||||
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
![]() |
|||||
Disease | Renal cancer | ||||
Tissue | Kidney | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.38 Z-score: -1.26 P-value: 1.48E-03 |
||||
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.12 Z-score: -0.62 P-value: 9.43E-03 |
||||
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
![]() |
|||||
Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
![]() |
|||||
Reference | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7882). | ||||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015430) | ||||
REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
REF 4 | Clinical pipeline report, company report or official report of MedImmune (2011). | ||||
REF 5 | 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.