Target General Information
Target ID	T54582
Target Name	Nicotinamide phosphoribosyltransferase
Synonyms	NAmPRTase; Nampt; PreB cellenhancing factor; PreBcell colonyenhancing factor 1; Visfatin; NAMPT
Target Type	Clinical Trial
Gene Name	NAMPT
Biochemical Class	Pentosyltransferase
UniProt ID	NAMPT_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Acute myelocytic leukemia
Example drug	Daporinad			Phase 2	[529259], [542710], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.63 Z-score: -0.59 P-value: 3.06E-08
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Reference
Ref 542710	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7745).
Ref 529259	Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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