Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T54582 | ||||
| Target Name | Nicotinamide phosphoribosyltransferase | ||||
| Synonyms | NAmPRTase; Nampt; PreB cellenhancing factor; PreBcell colonyenhancing factor 1; Visfatin; NAMPT | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | NAMPT | ||||
| Biochemical Class | Pentosyltransferase | ||||
| UniProt ID | NAMPT_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Acute myelocytic leukemia | ||||
| Example drug | Daporinad | Phase 2 | [1], [2], [3] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.63 Z-score: -0.59 P-value: 3.06E-08 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Reference | |||||
| REF 1 | Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7745). | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
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