Target General Information
Target ID	T56545
Target Name	Apolipoprotein A-I
Synonyms	ApoAI; Apolipoprotein A1; Truncated apolipoprotein AI; APOA1
Target Type	Clinical Trial
Gene Name	APOA1
Biochemical Class	Apolipoprotein
UniProt ID	APOA1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Coronary artery disease
Example drug	CSL-112			Phase 2	[524706], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.03 Z-score: -0.45 P-value: 8.72E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Aortic stenosis
Example drug	CER-522			Phase 1	[549195], [1572592]
Tissue	Calcified aortic valve
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.25 Z-score: -0.24 P-value: 2.95E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Arteriosclerosis
Example drug	MDCO-216			Phase 1	[547079], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.17 Z-score: 1.01 P-value: 1.44E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 547079	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012886)
Ref 549195	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033541)
Ref 524706	ClinicalTrials.gov (NCT02108262) A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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