Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T56697 | ||||
| Target Name | Dickkopf-related protein 1 | ||||
| Synonyms | Dickkopf1; Dickkopfrelated protein 1; Dkk1; SK; hDkk1; DKK1 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | DKK1 | ||||
| Biochemical Class | Dickkopf family | ||||
| UniProt ID | DKK1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Myeloma | ||||
| Example drug | BHQ-880 | Phase 2 | [523373], [1572592] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 2.97 Z-score: 5.21 P-value: 5.31E-07 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Osteoporosis | ||||
| Example drug | PF-04840082 | Phase 1 | [523352], [1572592] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.80 Z-score: -0.66 P-value: 2.29E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 523352 | ClinicalTrials.gov (NCT01293487) Safety And Tolerability Study Of RN564 In Women With Osteopenia And Healthy Men.. U.S. National Institutes of Health. | ||||
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