Target expression details

Target General Information
Target ID T58238
Target Name Activation B7-1 antigen
Synonyms Activation B7-1 antigen; B7; BB1; CD28LG; CD28LG1; CTLA-4 counter-receptor B7.1; LAB7; CD80
Target Type Successful
Gene Name CD80
UniProt ID CD80_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Rheumatoid arthritis
Example drug Abatacept Approved [536737], [541949], [1572592]
Tissue Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.22
Z-score: 0.55
P-value: 3.67E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Disease Lung cancer
Example drug HS-110 Phase 2 [524720], [1572592]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.12
Z-score: -0.30
P-value: 6.87E-07
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.06
Z-score: -0.13
P-value: 1.00E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 541949(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6891).
Ref 536737Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
Ref 524720ClinicalTrials.gov (NCT02117024) A Phase 2 Study of Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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