TTD | Expression Details

Target General Information
Target ID	T59328
Target Name	Epidermal growth factor receptor
Synonyms	EGFR-TK; Epidermal growth factor receptor ErbB-1; Epidermal growth factor receptor-tyrosine kinase; Receptor protein-tyrosine kinase ErbB-1; Proto-oncogene c-ErbB-1; EGFR
Target Type	Successful
Gene Name	EGFR
Biochemical Class	Kinase
UniProt ID	EGFR_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Breast cancer
Example drug	Lapatinib	Approved	[538585], [1572592]
Tissue	Breast tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.89 Z-score: -1.53 P-value: 1.04E-65
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.95 Z-score: -1.79 P-value: 2.77E-16
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Lung cancer
Example drug	Erlotinib	Approved	[468098], [527466], [1572592]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.04 Z-score: -0.09 P-value: 1.65E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.21 Z-score: -0.35 P-value: 1.58E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Rectal cancer
Example drug	Cetuximab	Approved	[527466], [541939], [1572592]
Tissue	Rectal colon tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.25 Z-score: -1.63 P-value: 1.07E-02
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.59 Z-score: -3.17 P-value: 1.24E-04
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Brain cancer
Example drug	Rindopepimut	Phase 3	[523703], [1572592]
Tissue	Nervous tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.06 Z-score: 0.13 P-value: 8.30E-26
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Gastric cancer
Example drug	DE-766	Phase 3	[550580], [550582], [1572592]
Tissue	Gastric tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.42 Z-score: -2.17 P-value: 2.52E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 0.31 Z-score: 0.57 P-value: 2.59E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Head and neck cancer
Example drug	Zalutumumab	Phase 3	[521892], [1572592]
Tissue	Head and neck tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.32 Z-score: 0.55 P-value: 5.84E-05
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Melanoma
Example drug	AZD9291	Phase 3	[525278], [542692], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.34 Z-score: -0.23 P-value: 1.60E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Bladder cancer
Example drug	Gefitinib	Phase 2	[468104], [536223], [1572592]
Tissue	Bladder tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.09 Z-score: 0.29 P-value: 5.87E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Glioma
Example drug	Erlotinib	Phase 2	[468098], [527466], [1572592]
Tissue	Brainstem tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.40 Z-score: 190.08 P-value: 2.09E-05
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Glioma
Example drug	Erlotinib	Phase 2	[468098], [527466], [1572592]
Tissue	White matter
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.39 Z-score: 1.69 P-value: 6.32E-04
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Ovarian cancer
Example drug	Gefitinib	Phase 2	[468104], [536223], [1572592]
Tissue	Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.01 Z-score: -0.03 P-value: 9.25E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -1.28 Z-score: -2.32 P-value: 6.76E-06
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Prostate cancer
Example drug	Gefitinib	Phase 2	[468104], [536223], [1572592]
Tissue	Prostate
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.59 Z-score: -0.82 P-value: 7.43E-04
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Psoriasis
Example drug	PD-153035	Discontinued in Phase 1	[545893], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.27 Z-score: -0.42 P-value: 1.86E-07
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 1.02 Z-score: 1.93 P-value: 1.31E-21
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Eosinophilic gastritis
Example drug	Heparin-EGF-like factor	Terminated	[533768], [533866], [1572592]
Tissue	Gastric antrum tissue
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 0.21 Z-score: 1.30 P-value: 7.00E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Disease	Ureter cancer
Tissue	Urothelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.07 Z-score: -0.71 P-value: 5.34E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 545893	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005268)
Ref 538585	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022059.
Ref 550580	Clinical pipeline report, company report or official report of Daiichi Sankyo.
Ref 550582	Clinical pipeline report, company report or official report of Daiichi Sankyo.
Ref 468098	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4920).
Ref 468104	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4941).
Ref 541939	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6882).
Ref 542692	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7719).
Ref 527466	2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.

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Target expression details

Prof. Feng ZHU

Prof. Yuzong CHEN