Target General Information
Target ID	T59631
Target Name	Programmed cell death PD-1
Synonyms	CD279; Programmed cell death protein 1; Protein PD1; hPD1; PDCD1
Target Type	Successful
Gene Name	PDCD1
Biochemical Class	Immunoglobulin
UniProt ID	PDCD1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Melanoma
Example drug	Pembrolizumab			Approved	[533123], [542518], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.01 Z-score: -0.03 P-value: 7.26E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 542518	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7499).
Ref 533123	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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