Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T60724 | ||||
| Target Name | Sclerostin | ||||
| Synonyms | SOST | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | SOST | ||||
| Biochemical Class | Sclerostin (SOST) | ||||
| UniProt ID | SOST_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Osteoporosis | ||||
| Example drug | Romosozumab | Phase 3 | [1], [2], [3] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.90 Z-score: 2.87 P-value: 1.11E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Reference | |||||
| REF 1 | ClinicalTrials.gov (NCT01631214) Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis. U.S. National Institutes of Health. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8092). | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
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