Target General Information
Target ID	T60724
Target Name	Sclerostin
Synonyms	SOST
Target Type	Clinical Trial
Gene Name	SOST
Biochemical Class	Sclerostin (SOST)
UniProt ID	SOST_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Osteoporosis
Example drug	Romosozumab			Phase 3	[523960], [542966], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.90 Z-score: 2.87 P-value: 1.11E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Reference
Ref 542966	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8092).
Ref 523960	ClinicalTrials.gov (NCT01631214) Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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