Target General Information
Target ID	T60857
Target Name	Dihydrodiol dehydrogenase type I
Synonyms	3-alpha-hydroxysteroid dehydrogenase; 3alpha-HSD; Chlordecone reductase homolog HAKRb; DD3; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase, type I; HA1753; HPGFS; Human prostaglandin F synthase; Prostaglandin F synthase; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; AKR1C3
Target Type	Successful
Gene Name	AKR1C3
Biochemical Class	Short-chain dehydrogenases reductases
UniProt ID	AK1C3_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Prostate cancer
Example drug	ASP-9521			Phase 1/2	[523469], [1572592]
Tissue	Prostate
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.39 Z-score: 0.74 P-value: 4.06E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 523469	ClinicalTrials.gov (NCT01352208) Phase I/II Study of ASP9521 in Castrate-Resistant Prostate Cancer (CRPC) Patients. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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