Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T62276 | ||||
| Target Name | Glutamate NMDA receptorsubunit zeta-1 | ||||
| Synonyms | GluN1; Glutamate [NMDA] receptor subunit zeta1; Glutamate receptor ionotropic, NMDA 1; NMDR1; NmethylDaspartate receptor subunit NR1; GRIN1 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | GRIN1 | ||||
| Biochemical Class | Glutamate-gated ion channel | ||||
| UniProt ID | NMDZ1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Multiple sclerosis | ||||
| Example drug | ELIPRODIL | Phase 2 | [521427], [1572592] | ||
| Tissue | Spinal cord | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.17 Z-score: -1.25 P-value: 2.00E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Disease | Parkinson's disease | ||||
| Tissue | Substantia nigra tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.50 Z-score: -1.80 P-value: 1.12E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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