Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T64795 | ||||
| Target Name | Voltage-dependent T-type calcium channel alpha-1G | ||||
| Synonyms | Cav; Cav3.1c; NBR13; Voltage-dependent T-type calcium channel; Voltage-gated calcium channel alpha subunit Cav3.1; CACNA1G | ||||
| Target Type | Successful | ||||
| Gene Name | CACNA1G | ||||
| Biochemical Class | Calcium channel | ||||
| UniProt ID | CAC1G_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Epilepsy | ||||
| Example drug | Ethosuximide | Approved | [538174], [542193], [1572592] | ||
| Tissue | Peritumoral cortex tissue | ||||
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
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| Disease | Schizophrenia | ||||
| Example drug | Penfluridol | Approved | [551871], [1572592] | ||
| Tissue | Pre-frontal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.06 Z-score: -0.18 P-value: 3.88E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Schizophrenia | ||||
| Example drug | Penfluridol | Approved | [551871], [1572592] | ||
| Tissue | Superior temporal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.01 Z-score: -0.03 P-value: 9.84E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 538174 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040253. | ||||
| Ref 542193 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7182). | ||||
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