Target General Information
Target ID	T65200
Target Name	Corticosteroid 11 beta dehydrogenase 1
Synonyms	11 beta-hydroxysteroid dehydrogenase type 1; 11-DH; 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11HSD1; 11beta-HSD1A; 11beta-HSD2; HSD11B1
Target Type	Clinical Trial
Gene Name	HSD11B1
Biochemical Class	Short-chain dehydrogenases reductases
UniProt ID	DHI1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Type 2 diabetes
Example drug	INCB13739			Phase 2a	[522347], [1572592]
Tissue	Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.01 Z-score: -0.08 P-value: 2.03E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Arteriosclerosis
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.11 Z-score: 0.56 P-value: 3.53E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Familial hypercholesterolemia
Tissue	Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.16 Z-score: -0.79 P-value: 1.35E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 522347	ClinicalTrials.gov (NCT00698230) Safety and Efficacy of INCB013739 Plus Metformin Compared to Metformin Alone on Glycemic Control in Type 2 Diabetics. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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