Target General Information
Target ID T65883
Target Name Claudin 18
Synonyms Claudin18; CLDN18
Target Type Clinical Trial
Gene Name CLDN18
Biochemical Class Claudin
UniProt ID CLD18_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Esophagal cancer
Example drug Claudiximab Phase 2 [523164], [1572592]
Tissue Esophagus
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.13
Z-score: 1.09
P-value: 1.75E-05
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 523164ClinicalTrials.gov (NCT01197885) Efficacy and Safety Study of Multiple Doses of IMAB362 in Patients With Advanced Gastroesophageal Cancer. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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