Target expression details
Target General Information | |||||
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Target ID | T67894 | ||||
Target Name | Toll-like receptor 3 | ||||
Synonyms | CD283; TLR3 | ||||
Target Type | Clinical Trial | ||||
Gene Name | TLR3 | ||||
Biochemical Class | Toll-like receptor family | ||||
UniProt ID | TLR3_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Glioma | ||||
Example drug | Poly-ICLC | Phase 2 | [1], [2] | ||
Tissue | Brainstem tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.63 Z-score: 0.83 P-value: 4.85E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Glioma | ||||
Example drug | Poly-ICLC | Phase 2 | [1], [2] | ||
Tissue | White matter | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.11 Z-score: 0.10 P-value: 8.00E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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Reference | |||||
REF 1 | Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10. | ||||
REF 2 | NCBI GEO: archive for functional genomics data sets--update. |
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