TTD | Expression Details

Target General Information
Target ID	T68251
Target Name	Matrix metalloproteinase-2
Synonyms	72 kDa gelatinase; Gelatinase A; MMP-2; Matrix metalloproteinase 2; Matrix metalloproteinase-2; TBE-1; MMP2
Target Type	Successful
Gene Name	MMP2
Biochemical Class	Peptidase
UniProt ID	MMP2_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Lung cancer
Example drug	Prinomastat	Approved	[536056], [541642], [1572592]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.03 Z-score: 0.10 P-value: 8.17E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 0.05 Z-score: 0.25 P-value: 4.79E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Prostate cancer
Example drug	Prinomastat	Approved	[536056], [541642], [1572592]
Tissue	Prostate
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.29 Z-score: -0.56 P-value: 3.15E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Osteoarthritis
Example drug	Tanomastat	Discontinued in Phase 3	[541603], [546781], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.07 Z-score: -0.50 P-value: 4.90E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Ovarian cancer
Example drug	Tanomastat	Discontinued in Phase 3	[541603], [546781], [1572592]
Tissue	Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.22 Z-score: -0.61 P-value: 8.96E-02
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 0.08 Z-score: 0.63 P-value: 5.64E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Renal cancer
Example drug	Neovastat	Discontinued in Phase 3	[537114], [1572592]
Tissue	Kidney
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.29 Z-score: -1.11 P-value: 1.23E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.24 Z-score: -0.80 P-value: 9.03E-06
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Sarcoma
Example drug	BMS 275291	Discontinued in Phase 3	[536608], [1572592]
Tissue	Muscle tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.11 Z-score: -0.43 P-value: 3.48E-16
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.11 Z-score: -0.57 P-value: 2.53E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Multiple sclerosis
Example drug	BB-1101	Terminated	[546101], [1572592]
Tissue	Spinal cord
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.02 Z-score: -0.08 P-value: 7.67E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Disease	Rheumatoid arthritis
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.25 Z-score: 0.83 P-value: 1.29E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 546101	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006361)
Ref 546781	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010243)
Ref 541603	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6468).
Ref 541642	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6505).
Ref 536056	Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs. 2005 Feb;10(1):95-108.
Ref 536608	Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer. 2008 Mar 1;112(5):1083-8.
Ref 537114	Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Target expression details

Prof. Feng ZHU

Prof. Yuzong CHEN