Target General Information
Target ID	T69085
Target Name	Transcription factor AP-1
Synonyms	AP-1 transcription factor; AP1; Activator protein 1; Activator protein-1; C-jun proto-oncogene; P39; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; JUN
Target Type	Discontinued
Gene Name	JUN
UniProt ID	JUN_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Rheumatoid arthritis
Example drug	T-5224			Discontinued in Phase 2	[1], [2]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.92 Z-score: 1.87 P-value: 1.13E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
REF 1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016746)
REF 2	NCBI GEO: archive for functional genomics data sets--update.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.