Target General Information
Target ID	T70518
Target Name	S-nitrosoglutathione reductase
Synonyms	15hydroxyprostaglandin dehydrogenase [NADP(+)]; Carbonyl reductase [NADPH] 1; NADPHdependent carbonyl reductase 1; Prostaglandin 9ketoreductase; ProstaglandinE(2) 9reductase; CBR1
Target Type	Clinical Trial
Gene Name	CBR1
Biochemical Class	Short-chain dehydrogenases reductases
UniProt ID	CBR1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Asthma
Example drug	N6022			Phase 2	[531801], [1572592]
Tissue	Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.71 Z-score: 0.77 P-value: 1.94E-06
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 531801	Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51(10):2157-68.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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