Target General Information
Target ID	T71928
Target Name	CD antigen CD158a
Synonyms	CD158 antigenlike family member A; Killer cell immunoglobulinlike receptor 2DL1; MHC class I NK cell receptor; NKAT1; Natural killerassociated transcript 1; p58 NK receptor CL42/47.11; p58 natural killer cell receptor clones CL42/47.11; p58.1 MHC classIspecific NK receptor; KIR2DL1
Target Type	Clinical Trial
Gene Name	KIR2DL1
Biochemical Class	Immunoglobulin
UniProt ID	KI2L1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Myeloma
Example drug	mab 1-7F9			Phase 2	[530228], [530238], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.43 Z-score: -4.42 P-value: 2.29E-06
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Acute myelocytic leukemia
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.32 Z-score: -0.63 P-value: 1.01E-12
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 530228	Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood. 2009 Sep 24;114(13):2667-77.
Ref 530238	Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12879-84.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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