Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T73476 | ||||
| Target Name | Antithrombin-III | ||||
| Synonyms | AT3; ATIII; SERPINC1 | ||||
| Target Type | Successful | ||||
| Gene Name | SERPINC1 | ||||
| Biochemical Class | Serpin family | ||||
| UniProt ID | ANT3_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | O-desulfated heparin | Phase 2 | [523672], [1572592] | ||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.04 Z-score: 0.35 P-value: 2.83E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | O-desulfated heparin | Phase 2 | [523672], [1572592] | ||
| Tissue | Small airway epithelium | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.02 Z-score: 0.14 P-value: 4.05E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Asthma | ||||
| Example drug | OPK-0018 | Phase 1 | [549239], [1572592] | ||
| Tissue | Nasal and bronchial airway | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.50E-03 Z-score: 6.15E-03 P-value: 9.48E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Ulcerative colitis | ||||
| Example drug | Deligoparin sodium | Discontinued in Phase 3 | [546061], [1572592] | ||
| Tissue | Colon mucosal tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.07 Z-score: 0.35 P-value: 6.36E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 546061 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006120) | ||||
| Ref 549239 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034071) | ||||
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