Target General Information
Target ID T76093
Target Name Proheparin-binding EGF-like growth factor
Synonyms DTR; Heparinbinding EGFlike growth factor; Proheparinbinding EGFlike growth factor; HBEGF
Target Type Clinical Trial
Gene Name HBEGF
Biochemical Class Growth factor
UniProt ID HBEGF_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Ovarian cancer
Example drug KHK-2866 Phase 1 [523323], [1572592]
Tissue Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.06
Z-score: 0.12
P-value: 3.92E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.02
Z-score: 0.02
P-value: 1.37E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 523323ClinicalTrials.gov (NCT01279291) Study of Anti-HB-EGF Antibody KHK2866 in Subjects With Advanced Solid Tumors and Ovarian Cancer. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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