Target General Information
Target ID T76285
Target Name Phosphodiesterase I beta
Synonyms ENPP3
Target Type Clinical Trial
Gene Name ENPP3
Biochemical Class Hydrolases (EC:3)
UniProt ID ENPP3_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Renal cancer
Example drug AGS-16M8F Phase 1 [523023], [1572592]
Tissue Kidney
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 3.44
Z-score: 9.16
P-value: 4.95E-20
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 3.34
Z-score: 2.84
P-value: 6.62E-21
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 523023ClinicalTrials.gov (NCT01114230) A First in Man Study to Determine the Safety at Various Dose Levels of AGS-16M8F in Advanced Kidney Cancer. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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