Target General Information
Target ID	T76369
Target Name	Liver carboxylesterase
Synonyms	ACAT; Acyl coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; HCE1; HMSE; Human carboxylesterase 1; Monocyte/macrophage serine esterase; Serine esterase 1; CES1
Target Type	Clinical Trial
Gene Name	CES1
Biochemical Class	Carboxylic ester hydrolase
UniProt ID	EST1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Arteriosclerosis
Example drug	PACTIMIBE			Phase 2/3	[521676], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.03 Z-score: -0.06 P-value: 1.13E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Familial hypercholesterolemia
Example drug	DuP-129			Terminated	[545519], [1572592]
Tissue	Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.86 Z-score: 1.90 P-value: 3.82E-08
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 545519	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003587)
Ref 521676	ClinicalTrials.gov (NCT00151788) Efficacy and Safety of the ACAT Inhibitor CS-505 (Pactimibe) for Reducing the Progression of Carotid Artery Disease. This Study is Also Known as CAPTIVATE.. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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