Target General Information
Target ID	T77796
Target Name	Thyrotropin-releasing hormone receptor
Synonyms	TRH-R; Thyroliberin receptor; TRHR
Target Type	Successful
Gene Name	TRHR
Biochemical Class	GPCR rhodopsin
UniProt ID	TRFR_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Parkinson's disease
Example drug	Posatirelin			Discontinued in Phase 3	[545969], [1572592]
Tissue	Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.11 Z-score: 0.61 P-value: 2.98E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 545969	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005568)
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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