Target expression details
Target General Information | |||||
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Target ID | T77796 | ||||
Target Name | Thyrotropin-releasing hormone receptor | ||||
Synonyms | TRH-R; Thyroliberin receptor; TRHR | ||||
Target Type | Successful | ||||
Gene Name | TRHR | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID | TRFR_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Parkinson's disease | ||||
Example drug | Posatirelin | Discontinued in Phase 3 | [1], [2] | ||
Tissue | Substantia nigra tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.11 Z-score: 0.61 P-value: 2.98E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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Reference | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005568) | ||||
REF 2 | NCBI GEO: archive for functional genomics data sets--update. |
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