Target General Information
Target ID	T78429
Target Name	Inhibitor of nuclear factor kappa B kinase beta
Synonyms	I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta; IkBKB; IkappaB kinase 2; IkappaB kinase beta; Inhibitory kappa B kinase b; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; IKBKB
Target Type	Clinical Trial
Gene Name	IKBKB
Biochemical Class	Kinase
UniProt ID	IKKB_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Alzheimer's disease
Example drug	IMD-1041			Phase 2	[532068], [1572592]
Tissue	Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.26 Z-score: 0.88 P-value: 5.74E-08
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Osteoarthritis
Example drug	SAR-113945			Phase 2	[523903], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.07 Z-score: 0.17 P-value: 5.64E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Rheumatoid arthritis
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.27 Z-score: 2.63 P-value: 1.28E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 532068	Inhibition of I?B phosphorylation prevents load-induced cardiac dysfunction in mice. Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1435-45.
Ref 523903	ClinicalTrials.gov (NCT01598415) Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients / Part II. U.S. National Institutes ofHealth.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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