Target General Information
Target ID	T78981
Target Name	Complement C5
Synonyms	C3 and PZPlike alpha2macroglobulin domaincontaining protein 4; Complement C5 alpha' chain; C5
Target Type	Clinical Trial
Gene Name	C5
Biochemical Class	Complement system
UniProt ID	CO5_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Rheumatoid arthritis
Example drug	NNC-0151-0000-0000			Phase 2	[1], [2]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.12 Z-score: -0.23 P-value: 7.69E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	MEDI7814			Phase 1	[3], [2]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.02 Z-score: -0.03 P-value: 8.42E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	MEDI7814			Phase 1	[3], [2]
Tissue	Small airway epithelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.15 Z-score: -0.43 P-value: 8.64E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
REF 1	Complement-targeted therapeutics. Nat Biotechnol. 2007 Nov;25(11):1265-75.
REF 2	NCBI GEO: archive for functional genomics data sets--update.
REF 3	ClinicalTrials.gov (NCT01544361) A Phase 1 Study to Evaluate the Safety of MEDI7814 in Adult Volunteers. U.S. National Institutes of Health.

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