Target General Information
Target ID	T79160
Target Name	Glial cell neurotrophic factor ligand
Synonyms	ATF; Astrocytederived trophic factor; Glial cell linederived neurotrophic factor; hGDNF; GDNF
Target Type	Clinical Trial
Gene Name	GDNF
Biochemical Class	Transforming growth factor
UniProt ID	GDNF_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Lateral sclerosis
Example drug	Liatermin			Phase 1/2	[521642], [1572592]
Tissue	Cervical spinal cord
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.08 Z-score: 0.31 P-value: 2.29E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 521642	ClinicalTrials.gov (NCT00111982) Trial of Extended Treatment With Liatermin (r-metHuGDNF) Administered by Continuous Intraputaminal (IPu)Infusion to Subjects With Idiopathic Parkinson's Disease Who Have Completed a Previous Trial of Liatermin. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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