Target General Information
Target ID	T82051
Target Name	mRNA of TP53
Synonyms	Antigen NYCO13 (mRNA); Cellular tumor antigen p53 (mRNA); Phosphoprotein p53 (mRNA); TP53 (mRNA); Tumor suppressor p53 (mRNA); TP53
Target Type	Clinical Trial
Gene Name	TP53
Biochemical Class	Target of siRNA drug
UniProt ID	P53_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Acute myelocytic leukemia
Example drug	Cenersen			Phase 2	[1], [2], [3]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.30 Z-score: 0.59 P-value: 7.90E-07
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
REF 1	Phase 2 randomized study of p53 antisense oligonucleotide (cenersen) plus idarubicin with or without cytarabine in refractory and relapsed acute myeloid leukemia. Cancer. 2012 Jan 15;118(2):418-27.
REF 2	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8270).
REF 3	NCBI GEO: archive for functional genomics data sets--update.

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