Target General Information
Target ID	T82577
Target Name	Angiotensin-converting enzyme
Synonyms	CD143 antigen; Dipeptidyl carboxypeptidase I; Kininase II; ACE
Target Type	Successful
Gene Name	ACE
Biochemical Class	Glycosylases
UniProt ID	ACE_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Depression
Example drug	Ceranapril			Discontinued in Phase 2	[544627], [1572592]
Tissue	Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.01 Z-score: -0.06 P-value: 2.62E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 544627	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000355)
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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