Target General Information
Target ID	T85467
Target Name	Prostaglandin E2 receptor EP3
Synonyms	PGE receptor, EP3 subtype; PGE2-R; Prostanoid EP3 receptor; PTGER3
Target Type	Clinical Trial
Gene Name	PTGER3
Biochemical Class	GPCR rhodopsin
UniProt ID	PE2R3_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Asthma
Example drug	GR-63799X			Discontinued in Phase 1	[539236], [545501], [1572592]
Tissue	Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 7.51E-03 Z-score: 0.03 P-value: 4.36E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 545501	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003508)
Ref 539236	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1937).
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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