Target expression details

Target General Information
Target ID T86652
Target Name mRNA of PCSK9
Synonyms mRNA of NARC-1; mRNA of Neural apoptosis-regulated convertase 1; mRNA of PC9; mRNA of PCSK9; mRNA of Proprotein convertase 9; mRNA of Subtilisin/kexin-like protease PC9; PCSK9
Target Type Clinical Trial
Gene Name PCSK9
Biochemical Class Peptidase
UniProt ID PCSK9_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Coronary artery disease
Example drug BMS-PCSK9 Preclinical [551053], [1572592]
Tissue Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.13
Z-score: -0.62
P-value: 9.13E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Disease Familial hypercholesterolemia
Example drug ALN-PCS Preclinical [550232], [1572592]
Tissue Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.07
Z-score: -0.30
P-value: 4.82E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Reference
Ref 550232Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011).
Ref 551053Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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