Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T86652 | ||||
| Target Name | mRNA of PCSK9 | ||||
| Synonyms | mRNA of NARC-1; mRNA of Neural apoptosis-regulated convertase 1; mRNA of PC9; mRNA of PCSK9; mRNA of Proprotein convertase 9; mRNA of Subtilisin/kexin-like protease PC9; PCSK9 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | PCSK9 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | PCSK9_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Coronary artery disease | ||||
| Example drug | BMS-PCSK9 | Preclinical | [1], [2] | ||
| Tissue | Peripheral blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.13 Z-score: -0.62 P-value: 9.13E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Familial hypercholesterolemia | ||||
| Example drug | ALN-PCS | Preclinical | [3], [2] | ||
| Tissue | Whole blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.07 Z-score: -0.30 P-value: 4.82E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Reference | |||||
| REF 1 | Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 3 | Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011). | ||||
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