Target expression details

Target General Information
Target ID T87075
Target Name T cell surface glycoprotein CD3 epsilon
Synonyms CD3e; T-cell surface antigen T3/Leu-4 epsilon chain; T3E; CD3E
Target Type Successful
Gene Name CD3E
UniProt ID CD3E_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Breast cancer
Example drug Ertumaxomab Phase 2 [529707], [531972], [1572592]
Tissue Breast tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.11
Z-score: 0.14
P-value: 1.62E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.31
Z-score: -0.49
P-value: 1.05E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data in the tissue of healthy individual
Disease Melanoma
Example drug Resimmune Phase 1/2 [549482], [1572592]
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 1.29
Z-score: 1.26
P-value: 1.70E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Disease Prostate cancer
Example drug Autologous T-cell therapy Phase 1 [525412], [1572592]
Tissue Prostate
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.93
Z-score: -1.37
P-value: 1.53E-06
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 549482Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038158)
Ref 529707Ertumaxomab: a trifunctional antibody for breast cancer treatment. Expert Opin Investig Drugs. 2008 Oct;17(10):1553-8.
Ref 531972Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012 Sep-Oct;4(5):614-22.
Ref 525412Clinical application of genetically modified T cells in cancer therapy. Clin Transl Immunology. 2014 May 16;3(5):e16. doi: 10.1038/cti.2014.7. eCollection 2014.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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