Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T87108 | ||||
| Target Name | Mesothelin | ||||
| Synonyms | CAK1 antigen; MPF; Mesothelin; Mesothelin, cleaved form; Prepromegakaryocytepotentiating factor; MSLN | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | MSLN | ||||
| Biochemical Class | Mesothelin | ||||
| UniProt ID | MSLN_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Pancreatic cancer | ||||
| Example drug | CRS-207 | Phase 2 | [524918], [1572592] | ||
| Tissue | Pancreas | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 3.98 Z-score: 6.12 P-value: 2.86E-20 |
||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 3.16 Z-score: 4.13 P-value: 6.78E-36 |
||||
|
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
|
|||||
| Disease | Ovarian cancer | ||||
| Example drug | RG7882 | Phase 1 | [548800], [1572592] | ||
| Tissue | Ovarian tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 5.44 Z-score: 1.92 P-value: 1.35E-02 |
||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 2.10 Z-score: 0.84 P-value: 1.88E-02 |
||||
|
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
|
|||||
| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
|
|||||
| Reference | |||||
| Ref 548800 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028960) | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.