Target General Information
Target ID	T87686
Target Name	Histone-lysine N-methyltransferase
Synonyms	DOT1like protein; H3K79HMTase; Histone H3K79 methyltransferase; Histonelysine Nmethyltransferase, H3 lysine79 specific; Lysine Nmethyltransferase 4; DOT1L
Target Type	Clinical Trial
Gene Name	DOT1L
Biochemical Class	Methyltransferase superfamily
UniProt ID	DOT1L_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Acute myelocytic leukemia
Example drug	EPZ-5676			Phase 1	[524761], [542044], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.08 Z-score: 0.20 P-value: 7.62E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 542044	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7019).
Ref 524761	ClinicalTrials.gov (NCT02141828) Dose Escalation Study of EPZ-5676 in Pediatric Patients With Leukemias Bearing a Rearrangement of the MLL Gene. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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