Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T88304 | ||||
| Target Name | DNA methyltransferase HsaI | ||||
| Synonyms | CXXCtype zinc finger protein 9; DNA (cytosine5)methyltransferase 1; DNA MTase HsaI; DNA methyltransferase HsaI; Dnmt1; M.HsaI; MCMT; DNMT1 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | DNMT1 | ||||
| Biochemical Class | Methyltransferase superfamily | ||||
| UniProt ID | DNMT1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Acute myelocytic leukemia | ||||
| Example drug | SGI110 | Phase 3 | [525074], [1572592] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.11 Z-score: -0.34 P-value: 6.48E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Myelodysplastic syndromes | ||||
| Example drug | CC-486 | Phase 3 | [549703], [1572592] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.09 Z-score: 0.32 P-value: 5.50E-01 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.99 Z-score: 1.58 P-value: 4.61E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Lung cancer | ||||
| Example drug | Antroquinonol | Phase 2 | [524616], [1572592] | ||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.73 Z-score: 2.22 P-value: 1.56E-81 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.57 Z-score: 2.09 P-value: 5.94E-48 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Sarcoma | ||||
| Example drug | Palifosfamide | Phase 2 | [524236], [1572592] | ||
| Tissue | Muscle tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 2.46 Z-score: 4.65 P-value: 0.00E+00 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 2.56 Z-score: 7.16 P-value: 6.10E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Glioma | ||||
| Tissue | Brainstem tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.71 Z-score: 15.47 P-value: 2.06E-08 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Glioma | ||||
| Tissue | White matter | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.97 Z-score: 2.41 P-value: 1.27E-05 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 524236 | ClinicalTrials.gov (NCT01808534) Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors. U.S. National Institutes of Health. | ||||
| Ref 524616 | ClinicalTrials.gov (NCT02047344) Efficacy, Safety and Pharmacokinetics Study of Antroquinonol to Treat NSCLC. U.S. National Institutes of Health. | ||||
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