Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T91023 | ||||
| Target Name | Roof plate-specific spondin-1 | ||||
| Synonyms | R-spondin-1; hRspo1; RSPO1 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | RSPO1 | ||||
| Biochemical Class | R-spondin | ||||
| UniProt ID | RSPO1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Eosinophilic gastritis | ||||
| Example drug | NU-206 | Phase 1 | [1], [2], [3] | ||
| Tissue | Gastric antrum tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.01 Z-score: -0.26 P-value: 4.37E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Reference | |||||
| REF 1 | R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5. Epub 2007 Sep 5. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3697). | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
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