TTD | Expression Details

Target General Information
Target ID	T91023
Target Name	Roof plate-specific spondin-1
Synonyms	R-spondin-1; hRspo1; RSPO1
Target Type	Clinical Trial
Gene Name	RSPO1
Biochemical Class	R-spondin
UniProt ID	RSPO1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Eosinophilic gastritis
Example drug	NU-206			Phase 1	[529021], [540504], [1572592]
Tissue	Gastric antrum tissue
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.01 Z-score: -0.26 P-value: 4.37E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Reference
Ref 540504	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3697).
Ref 529021	R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5. Epub 2007 Sep 5.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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