Target expression details
Target General Information | |||||
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Target ID | T93344 | ||||
Target Name | Squalene monooxygenase | ||||
Synonyms | ERG1; Oxidosqaulene cyclase; SE; Squalene epoxidase; SQLE | ||||
Target Type | Successful | ||||
Gene Name | SQLE | ||||
Biochemical Class | Oxidoreductases acting on paired donors | ||||
UniProt ID | ERG1_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Coronary artery disease | ||||
Example drug | SDZ-87-469 | Terminated | [551702], [1572592] | ||
Tissue | Peripheral blood | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.19 Z-score: 1.16 P-value: 5.26E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Familial hypercholesterolemia | ||||
Example drug | FR-194738 | Terminated | [546677], [1572592] | ||
Tissue | Whole blood | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.45 Z-score: 2.51 P-value: 7.14E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Atopic dermatitis | ||||
Tissue | Skin | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.65 Z-score: -2.30 P-value: 2.61E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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