Target General Information
Target ID T93344
Target Name Squalene monooxygenase
Synonyms ERG1; Oxidosqaulene cyclase; SE; Squalene epoxidase; SQLE
Target Type Successful
Gene Name SQLE
Biochemical Class Oxidoreductases acting on paired donors
UniProt ID ERG1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Coronary artery disease
Example drug SDZ-87-469 Terminated [551702], [1572592]
Tissue Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.19
Z-score: 1.16
P-value: 5.26E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Familial hypercholesterolemia
Example drug FR-194738 Terminated [546677], [1572592]
Tissue Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.45
Z-score: 2.51
P-value: 7.14E-03
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Atopic dermatitis
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.65
Z-score: -2.30
P-value: 2.61E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref
Ref 546677Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009590)
Ref 551702Chemotherapy of fungal diseases. 1990. Page(525-550).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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