Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T97947 | ||||
| Target Name | Guanylyl cyclase C | ||||
| Synonyms | GC-C; GCC; HSTAR; Intestinal guanylate cyclase; STA receptor; GUCY2C | ||||
| Target Type | Successful | ||||
| Gene Name | GUCY2C | ||||
| Biochemical Class | Phosphorus-oxygen lyases | ||||
| UniProt ID | GUC2C_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Gastric cancer | ||||
| Example drug | MLN0264 | Phase 2 | [1], [2] | ||
| Tissue | Gastric tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 2.35 Z-score: 5.13 P-value: 9.52E-03 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 1.35 Z-score: 0.78 P-value: 1.11E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Irritable bowel syndrome | ||||
| Example drug | MD-1100 | Phase 2 | [3], [2] | ||
| Tissue | Rectal colon tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.31 Z-score: -0.55 P-value: 2.18E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | ClinicalTrials.gov (NCT02202759) A Study of MLN0264 in Patients With Cancer of the Stomach or Gastroesophageal Junction. U.S. National Institutes of Health. | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 3 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | ||||
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