Target expression details

Target General Information
Target ID T97947
Target Name Guanylyl cyclase C
Synonyms GC-C; GCC; HSTAR; Intestinal guanylate cyclase; STA receptor; GUCY2C
Target Type Successful
Gene Name GUCY2C
Biochemical Class Phosphorus-oxygen lyases
UniProt ID GUC2C_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Gastric cancer
Example drug MLN0264 Phase 2 [524850], [1572592]
Tissue Gastric tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 2.35
Z-score: 5.13
P-value: 9.52E-03
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 1.35
Z-score: 0.78
P-value: 1.11E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data in the tissue of healthy individual
Disease Irritable bowel syndrome
Example drug MD-1100 Phase 2 [532210], [1572592]
Tissue Rectal colon tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.31
Z-score: -0.55
P-value: 2.18E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 524850ClinicalTrials.gov (NCT02202759) A Study of MLN0264 in Patients With Cancer of the Stomach or Gastroesophageal Junction. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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