Target expression details

Target General Information
Target ID T98269
Target Name Caspase-1
Synonyms CASP-1; Caspase-1; ICE; IL-1 beta converting enzyme; IL-1BC; Interleukin-1 beta converting enzyme; P45; CASP1
Target Type Clinical Trial
Gene Name CASP1
Biochemical Class Peptidase
UniProt ID CASP1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Rheumatoid arthritis
Example drug PRALNACASAN Phase 2 [526728], [541602], [1572592]
Tissue Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.68
Z-score: 0.61
P-value: 1.73E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Disease Epilepsy
Example drug Belnacasan Phase 2 [1584204], [1572592]
Tissue Peritumoral cortex tissue
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of the persons with other diseases not directly affecting the tissue
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 541602(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6467).
Ref 526728Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46.
Ref 1584204A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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