Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T98269 | ||||
| Target Name | Caspase-1 | ||||
| Synonyms | CASP-1; Caspase-1; ICE; IL-1 beta converting enzyme; IL-1BC; Interleukin-1 beta converting enzyme; P45; CASP1 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | CASP1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | CASP1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Rheumatoid arthritis | ||||
| Example drug | PRALNACASAN | Phase 2 | [1], [2], [3] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.68 Z-score: 0.61 P-value: 1.73E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Epilepsy | ||||
| Example drug | Belnacasan | Phase 2 | [4], [3] | ||
| Tissue | Peritumoral cortex tissue | ||||
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6467). | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 4 | A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety | ||||
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