Target General Information
Target ID T99948
Target Name Programmed death ligand PD-L1
Synonyms B7 homolog 1; B7H1; PDCD1 ligand 1; PDL1; Programmed cell death 1 ligand 1; Programmed death ligand 1; CD274
Target Type Successful
Gene Name CD274
Biochemical Class Immunoglobulin
UniProt ID PD1L1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Bladder cancer
Example drug RG-7446 Phase 3 [1], [2]
Tissue Bladder tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.37
Z-score: 2.10
P-value: 4.38E-07
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Reference
REF 12016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.
REF 2NCBI GEO: archive for functional genomics data sets--update.

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