Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T15167
|
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| Former ID |
TTDI01960
|
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| Target Name |
Collagen I
|
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| Gene Name |
COL1A2
|
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| Synonyms |
COL1A2
|
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| Target Type |
Clinical Trial
|
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| Disease | Scleroderma [ICD9: 701.0710.1; ICD10: L94.0-L94.1, M34] | ||||
| BioChemical Class |
Fibrillar collagen family
|
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| UniProt ID | |||||
| Sequence |
MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTG
PPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEP GEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIR GHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSV GPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNP GANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNK GEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPP GSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPI GPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQ GGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAA GPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEP GLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPA GPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDG GPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPP GFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIA GPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAA GAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLP GLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIR GPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLK SLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTG ETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLL ANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKK TNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK |
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| Drugs and Mode of Action | |||||
| Modulator | Solubilized type 1 native bovine collagen | Drug Info | |||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | PI3K-Akt signaling pathway | ||||
| Focal adhesion | |||||
| ECM-receptor interaction | |||||
| Platelet activation | |||||
| Protein digestion and absorption | |||||
| Amoebiasis | |||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | GPVI-mediated activation cascade | ||||
| Collagen degradation | |||||
| Collagen biosynthesis and modifying enzymes | |||||
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| Cell surface interactions at the vascular wall | |||||
| Integrin cell surface interactions | |||||
| Anchoring fibril formation | |||||
| Syndecan interactions | |||||
| Non-integrin membrane-ECM interactions | |||||
| ECM proteoglycans | |||||
| Scavenging by Class A Receptors | |||||
| Platelet Adhesion to exposed collagen | |||||
| WikiPathways | Senescence and Autophagy in Cancer | ||||
| Inflammatory Response Pathway | |||||
| Osteoblast Signaling | |||||
| Focal Adhesion | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| Binding and Uptake of Ligands by Scavenger Receptors | |||||
| Collagen biosynthesis and modifying enzymes | |||||
| Nanoparticle-mediated activation of receptor signaling | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| References | |||||
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