Target Information

Target General Infomation
Target ID
T15803
Former ID
TTDC00330
Target Name
mRNA of Factor XI
Gene Name
F11
Synonyms
mRNA of Coagulation factor XI; mRNA of FXI; mRNA of PTA; mRNA of Plasma thromboplastin antecedent; F11
Target Type
Clinical Trial
Disease Alzheimer disease [ICD9: 331; ICD10: G30]
Clotting disorders [ICD9: 286; ICD10: D65-D69]
Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10: I80-I82]
Function
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
BioChemical Class
Target of antisense drug
UniProt ID
P03951
EC Number
EC 3.4.21.27
Sequence
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
Drugs and Mode of Action
Drug(s) ISIS-FXI Drug Info Phase 1 Clotting disorders [551052]
alpha-ketothiazole analogue 36 Drug Info Clinical trial Alzheimer disease [541673]
Inhibitor alpha-ketothiazole analogue 36 Drug Info [529193]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Complement and coagulation cascades
PathWhiz Pathway Coagulation
Reactome Intrinsic Pathway of Fibrin Clot Formation
WikiPathways Human Complement System
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 541673(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6549).
Ref 551052Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
Ref 529193Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Ref 543604(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2360).
Ref 551052Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).

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