Target Information

Target General Infomation
Target ID
T15882
Former ID
TTDI02312
Target Name
Leukocyte proteinase-3
Gene Name
PRTN3
Synonyms
AGP7; CANCA antigen; Leukocyte proteinase 3; Myeloblastin; NP4; Neutrophil proteinase 4; P29; PR3; Wegener autoantigen; PRTN3
Target Type
Clinical Trial
Disease Myeloid leukemia [ICD9: 208.9; ICD10: C92]
Myocardial infarction [ICD9: 410; ICD10: I21, I22]
Function
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
BioChemical Class
Peptidase
UniProt ID
P24158
EC Number
EC 3.4.21.76
Sequence
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTL
IHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVL
LIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTF
FCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYV
DWIRSTLRRVEAKGRP
Drugs and Mode of Action
Drug(s) Combined PR1/WT1 vaccine Drug Info Phase 2 Myeloid leukemia [533145]
Tiprelestat Drug Info Phase 2 Myocardial infarction [548073]
Inhibitor compound 4g Drug Info [531910]
Modulator Tiprelestat Drug Info
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
Pathway Interaction Database C-MYB transcription factor network
Reactome Common Pathway of Fibrin Clot Formation
References
Ref 533145Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies. Front Immunol. 2015 Feb 4;6:36.
Ref 548073Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021706)
Ref 529050Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42. Epub 2007 Sep 17.
Ref 531910N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3993-7.

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