Target Information

Target General Infomation
Target ID
T16340
Former ID
TTDI01935
Target Name
Interleukin-1 alpha ligand
Gene Name
IL1A
Synonyms
Hematopoietin1; IL1 alpha; Interleukin1 alpha; IL1A
Target Type
Clinical Trial
Disease Atherosclerosis [ICD9: 414.0, 440; ICD10: I70]
Osteoarthritis [ICD9: 715; ICD10: M15-M19, M47]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Unspecified [ICD code not available]
Function
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
BioChemical Class
Cytokine: interleukin
UniProt ID
P01583
Sequence
MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETS
KTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLS
NVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKI
TVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHP
NLFIATKQDYWVCLAGGPPSITDFQILENQA
Drugs and Mode of Action
Drug(s) ABT-981 Drug Info Phase 2 Osteoarthritis [889392], [889410]
IX207-887 Drug Info Discontinued in Phase 2 Rheumatoid arthritis [545177]
IL1aQb Drug Info Terminated Atherosclerosis [548077]
Modulator ABT-981 Drug Info [533176]
Interleukin-1-alpha - Amgen/Roche Drug Info
IX207-887 Drug Info [532430]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
Apoptosis
Osteoclast differentiation
Hematopoietic cell lineage
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Prion diseases
Salmonella infection
Pertussis
Leishmaniasis
Tuberculosis
Measles
Influenza A
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Graft-versus-host disease
NetPath Pathway IL5 Signaling Pathway
IL1 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database IL1-mediated signaling events
Validated transcriptional targets of deltaNp63 isoforms
a6b1 and a6b4 Integrin signaling
Reactome Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 signaling
Interleukin-1 processing
WikiPathways SIDS Susceptibility Pathways
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Cytokines and Inflammatory Response
Hypertrophy Model
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Hematopoietic Stem Cell Differentiation
Structural Pathway of Interleukin 1 (IL-1)
Spinal Cord Injury
Allograft Rejection
IL-1 signaling pathway
Interleukin-1 signaling
References
Ref 545177Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002363)
Ref 548077Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021743)
Ref 889392ClinicalTrials.gov (NCT02087904) A Phase 2a Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis
Ref 889410ClinicalTrials.gov (NCT02384538) A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoarthritis
Ref 532430Inhibition of interleukin-1 release by IX 207-887. Agents Actions. 1990 Jun;30(3-4):350-62.
Ref 533176Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta. MAbs. 2015;7(3):605-19.
Ref 551585Cytos Biotechnology AG - Product Pipeline Review - 2013. Global Markets Direct. Dec 2013.

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