Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T23797
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| Former ID |
TTDI02101
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| Target Name |
Interleukin-33
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| Gene Name |
IL33
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| Synonyms |
IL1F11; Interleukin1 family member 11; NFHEV; Nuclear factor from high endothelial venules; IL33
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| Target Type |
Clinical Trial
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| Disease | Asthma [ICD10: J45] | ||||
| Function |
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin- associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
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| BioChemical Class |
Cytokine: interleukin
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| UniProt ID | |||||
| Sequence |
MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF
RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI GVKDNHLALIKVDSSENLCTENILFKLSET |
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| Drugs and Mode of Action | |||||
| Drug(s) | AMG 282 | Drug Info | Phase 1 | Asthma | [1] |
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Cytosolic DNA-sensing pathway | ||||
| Influenza A | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT02170337) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polyps. U.S. National Institutes of Health. | ||||
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