Target Information

Target General Infomation
Target ID
T23797
Former ID
TTDI02101
Target Name
Interleukin-33
Gene Name
IL33
Synonyms
IL1F11; Interleukin1 family member 11; NFHEV; Nuclear factor from high endothelial venules; IL33
Target Type
Clinical Trial
Disease Asthma [ICD10: J45]
Function
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin- associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
BioChemical Class
Cytokine: interleukin
UniProt ID
O95760
Sequence
MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF
RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT
EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK
MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI
GVKDNHLALIKVDSSENLCTENILFKLSET
Drugs and Mode of Action
Drug(s) AMG 282 Drug Info Phase 1 Asthma [524803]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytosolic DNA-sensing pathway
Influenza A
References
Ref 524803ClinicalTrials.gov (NCT02170337) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polyps. U.S. National Institutes of Health.
Ref 550251Clinical pipeline report, company report or official report of Amgen.

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