Target Information

Target General Infomation
Target ID
T28705
Former ID
TTDR01413
Target Name
mRNA of Caspase 8
Gene Name
CASP8
Synonyms
Apoptotic cysteine protease (mRNA); Apoptotic protease Mch5 (mRNA); CAP4 (mRNA); CASP8 (mRNA); Caspase8 (mRNA); Caspase8 subunit p10 (mRNA); FADDhomologous ICE/ced3like protease (mRNA); FADDlike ICE (mRNA); FLICE (mRNA); ICElike apoptotic protease 5 (mRNA); MACH (mRNA); MORT1associated ced3 homolog (mRNA); CASP8
Target Type
Research
BioChemical Class
Peptidase
Target Validation
T28705
UniProt ID
Q14790
EC Number
EC 3.4.22.61
Sequence
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Inhibitor Ac-IETD-CHO Drug Info [530042]
compound 4 Drug Info [526447]
Isoquinoline-1,3,4(2H)-trione Drug Info [528057]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway p53 signaling pathway
Apoptosis
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
TNF signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer&#039
s disease
Huntington&#039
Legionellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis B
Herpes simplex infection
Pathways in cancer
Viral carcinogenesis
Viral myocarditis
PANTHER Pathway Apoptosis signaling pathway
FAS signaling pathway
Huntington disease
Pathway Interaction Database Coregulation of Androgen receptor activity
TRAIL signaling pathway
FAS (CD95) signaling pathway
TNF receptor signaling pathway
Ceramide signaling pathway
Integrins in angiogenesis
Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Reactome Apoptotic cleavage of cellular proteins
Ligand-dependent caspase activation
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response
Apoptosis Modulation by HSP70
FAS pathway and Stress induction of HSP regulation
MyD88-independent cascade
Apoptosis
Nanoparticle triggered regulated necrosis
Integrated Pancreatic Cancer Pathway
Parkin-Ubiquitin Proteasomal System pathway
Allograft Rejection
AGE/RAGE pathway
TNF alpha Signaling Pathway
Prostate Cancer
Alzheimers Disease
TWEAK Signaling Pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Intrinsic Pathway for Apoptosis
Extrinsic Pathway for Apoptosis
Apoptotic execution phase
Apoptosis Modulation and Signaling
miRNA Regulation of DNA Damage Response
Regulation of toll-like receptor signaling pathway
NOD pathway
References
Ref 526447Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem. 2002 Nov 7;45(23):5005-22.
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Ref 530042J Med Chem. 2009 Apr 23;52(8):2188-91.Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Ref 549634US patent application no. 6,258,600, Antisense modulation of caspase 8 expression.

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