| Target General Infomation |
| Target ID |
T28705
|
| Former ID |
TTDR01413
|
| Target Name |
mRNA of Caspase 8
|
| Gene Name |
CASP8
|
| Synonyms |
Apoptotic cysteine protease (mRNA); Apoptotic protease Mch5 (mRNA); CAP4 (mRNA); CASP8 (mRNA); Caspase8 (mRNA); Caspase8 subunit p10 (mRNA); FADDhomologous ICE/ced3like protease (mRNA); FADDlike ICE (mRNA); FLICE (mRNA); ICElike apoptotic protease 5 (mRNA); MACH (mRNA); MORT1associated ced3 homolog (mRNA); CASP8
|
| Target Type |
Research
|
| BioChemical Class |
Peptidase
|
| Target Validation |
T28705
|
| UniProt ID |
|
| EC Number |
EC 3.4.22.61
|
| Sequence |
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
|
| Inhibitor |
Ac-IETD-CHO |
Drug Info |
[1] |
|---|
| compound 4 |
Drug Info |
[2] |
| Isoquinoline-1,3,4(2H)-trione |
Drug Info |
[3] |
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) |
| TEP |
EXP Info
|
| Pathways |
|
KEGG Pathway
|
p53 signaling pathway
|
|
Apoptosis
|
|
Toll-like receptor signaling pathway
|
|
NOD-like receptor signaling pathway
|
|
RIG-I-like receptor signaling pathway
|
|
TNF signaling pathway
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Alzheimer'
|
|
s disease
|
|
Huntington'
|
|
Legionellosis
|
|
Chagas disease (American trypanosomiasis)
|
|
Toxoplasmosis
|
|
Tuberculosis
|
|
Hepatitis B
|
|
Herpes simplex infection
|
|
Pathways in cancer
|
|
Viral carcinogenesis
|
|
Viral myocarditis
|
|
PANTHER Pathway
|
Apoptosis signaling pathway
|
|
FAS signaling pathway
|
|
Huntington disease
|
|
Pathway Interaction Database
|
Coregulation of Androgen receptor activity
|
|
TRAIL signaling pathway
|
|
FAS (CD95) signaling pathway
|
|
TNF receptor signaling pathway
|
|
Ceramide signaling pathway
|
|
Integrins in angiogenesis
|
|
Negative effector of Fas and TNF-alpha
|
|
Caspase Cascade in Apoptosis
|
|
Reactome
|
Apoptotic cleavage of cellular proteins
|
|
Ligand-dependent caspase activation
|
|
NOD1/2 Signaling Pathway
|
|
TRIF-mediated programmed cell death
|
|
Caspase-mediated cleavage of cytoskeletal proteins
|
|
Regulation by c-FLIP
|
|
RIPK1-mediated regulated necrosis
|
|
CASP8 activity is inhibited
|
|
TNFR1-induced proapoptotic signaling
|
|
Regulation of TNFR1 signaling
|
|
CLEC7A/inflammasome pathway
|
|
Regulation of necroptotic cell death
|
|
Dimerization of procaspase-8
|
|
FasL/ CD95L signaling
|
|
TRAIL signaling
|
|
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
|
|
WikiPathways
|
Toll-like receptor signaling pathway
|
|
DNA Damage Response
|
|
Apoptosis Modulation by HSP70
|
|
FAS pathway and Stress induction of HSP regulation
|
|
MyD88-independent cascade
|
|
Apoptosis
|
|
Nanoparticle triggered regulated necrosis
|
|
Integrated Pancreatic Cancer Pathway
|
|
Parkin-Ubiquitin Proteasomal System pathway
|
|
Allograft Rejection
|
|
AGE/RAGE pathway
|
|
TNF alpha Signaling Pathway
|
|
Prostate Cancer
|
|
Alzheimers Disease
|
|
TWEAK Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
Integrated Cancer pathway
|
|
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
|
|
Intrinsic Pathway for Apoptosis
|
|
Extrinsic Pathway for Apoptosis
|
|
Apoptotic execution phase
|
|
Apoptosis Modulation and Signaling
|
|
miRNA Regulation of DNA Damage Response
|
|
Regulation of toll-like receptor signaling pathway
|
|
NOD pathway
|
| References |
| REF 1 | J Med Chem. 2009 Apr 23;52(8):2188-91.Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. |
|---|
| REF 2 | Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem. 2002 Nov 7;45(23):5005-22. |
|---|
| REF 3 | J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. |
|---|
