Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T54779
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| Former ID |
TTDI02259
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| Target Name |
mRNA of Ribonucleotide reductase R2 component
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| Gene Name |
RRM2
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| Synonyms |
RRM2 (mRNA); Ribonucleoside-diphosphate reductase subunit M2 (mRNA); Ribonucleotide reductasesmall chain (mRNA); Ribonucleotide reductasesmall subunit (mRNA); RRM2
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| Target Type |
Research
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| Function |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
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| BioChemical Class |
Target of siRNA drug
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| UniProt ID | |||||
| EC Number |
EC 1.17.4.1
|
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| Sequence |
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN FFEKRVGEYQRMGVMSSPTENSFTLDADF |
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| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| BioCyc Pathway | Pyrimidine deoxyribonucleotides biosynthesis from CTP | ||||
| Pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
| Guanosine nucleotides de novo biosynthesis | |||||
| Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
| Superpathway of purine nucleotide salvage | |||||
| Purine nucleotides de novo biosynthesis | |||||
| Adenosine deoxyribonucleotides de novo biosynthesis | |||||
| Guanosine deoxyribonucleotides de novo biosynthesis | |||||
| KEGG Pathway | Purine metabolism | ||||
| Pyrimidine metabolism | |||||
| Glutathione metabolism | |||||
| Metabolic pathways | |||||
| p53 signaling pathway | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| PANTHER Pathway | p53 pathway | ||||
| De novo purine biosynthesis | |||||
| De novo pyrimidine deoxyribonucleotide biosynthesis | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| PathWhiz Pathway | Purine Metabolism | ||||
| Pyrimidine Metabolism | |||||
| Reactome | E2F mediated regulation of DNA replication | ||||
| G1/S-Specific Transcription | |||||
| WikiPathways | Nucleotide Metabolism | ||||
| Retinoblastoma (RB) in Cancer | |||||
| Metabolism of nucleotides | |||||
| Fluoropyrimidine Activity | |||||
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