Target Information

Target General Infomation
Target ID
T58920
Target Name
Thyrotropin releasing hormone
Gene Name
TRH
Synonyms
TRH
Target Type
Clinical Trial
Disease Dementia [ICD9: 290-294; ICD10: F01-F07]
Parkinson's disease [ICD9: 332; ICD10: G20]
UniProt ID
P20396
Sequence
MPGPWLLLALALTLNLTGVPGGRAQPEAAQQEAVTAAEHPGLDDFLRQVERLLFLRENIQ
RLQGDQGEHSASQIFQSDWLSKRQHPGKREEEEEEGVEEEEEEEGGAVGPHKRQHPGRRE
DEASWSVDVTQHKRQHPGRRSPWLAYAVPKRQHPGRRLADPKAQRSWEEEEEEEEREEDL
MPEKRQHPGKRALGGPCGPQGAYGQAGLLLGLLDDLSRSQGAEEKRQHPGRRAAWVREPL
EE
Drugs and Mode of Action
Drug(s) KPS-0373 Drug Info Phase 3 Parkinson's disease [524490]
RX-77368 Drug Info Discontinued in Phase 2 Dementia [544846]
Modulator KPS-0373 Drug Info
RX-77368 Drug Info
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 524490ClinicalTrials.gov (NCT01970111) An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD). U.S. National Institutes of Health.
Ref 544846Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001316)

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