Target Information

Target General Infomation
Target ID
T60433
Former ID
TTDS00472
Target Name
T-cell surfaceglycoprotein CD1a
Gene Name
CD1A
Synonyms
CD1a; T-cell surfaceantigen T6/Leu-6; hTa1 thymocyteantigen; CD1A
Target Type
Successful
Disease Aplastic anemia [ICD9: 284; ICD10: D60-D61]
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
BioChemical Class
Immunoglobulin
UniProt ID
P06126
Sequence
MLFLLLPLLAVLPGDGNADGLKEPLSFHVTWIASFYNHSWKQNLVSGWLSDLQTHTWDSN
SSTIVFLCPWSRGNFSNEEWKELETLFRIRTIRSFEGIRRYAHELQFEYPFEIQVTGGCE
LHSGKVSGSFLQLAYQGSDFVSFQNNSWLPYPVAGNMAKHFCKVLNQNQHENDITHNLLS
DTCPRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGHLQLVCHVSGFYPKPVWVMWMRG
EQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADLSCRVKHSSLEGQDIVLYWEHHSSV
GFIILAVIVPLLLLIGLALWFRKRCFC
Drugs and Mode of Action
Drug(s) Antithymocyte globulin Drug Info Approved Aplastic anemia [550542]
Binder Antithymocyte globulin Drug Info [536350]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Hematopoietic cell lineage
References
Ref 550542Approval information for Divalproex Sodium (approved in 1996). 1996.
Ref 536350Acute sensory neuropathy associated with rabbit antithymocyte globulin. Am J Transplant. 2007 Feb;7(2):484-6.

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